The selective activation of specific C–F bonds in polyfluoroarenes remains challenging. Now, the selective arylation of atypical C–F bonds in polyfluoroarenes is achieved through a photoexcited nickel-catalysed cross-electrophile coupling reaction with aryl chlorides, facilitated by a synergistic lithium salt effect.
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References
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This is a summary of: Liu, Z. et al. Selective arylation of atypical C–F bonds in polyfluoroarenes with aryl chlorides. Nat. Chem. https://doi.org/10.1038/s41557-025-01962-1 (2025).
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Cross-electrophile coupling of polyfluoroarenes and aryl chlorides. Nat. Chem. 17, 1641–1642 (2025). https://doi.org/10.1038/s41557-025-01961-2
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DOI: https://doi.org/10.1038/s41557-025-01961-2
