Fig. 1: Schematic for G4L-PROTACs. | Nature Chemistry

Fig. 1: Schematic for G4L-PROTACs.

From: Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras

Fig. 1: Schematic for G4L-PROTACs.The alt text for this image may have been generated using AI.

a, A G-tetrad, formed by four Hoogsteen base-paired guanines stabilized by a monovalent cation M+ (top), and a parallel G4 structure composed of stacked G-tetrads (bottom). b, A schematic representation of the G4L-PROTAC strategy. The G4L-PROTAC consists of a small-molecule G4-binding ligand coupled to an E3 ligase recruiter via a linker. Upon treatment, the G4L-PROTAC binds to G4 structures in chromatin to bring the E3 ligase proximal to nearby proteins. This facilitates the ubiquitination of G4-associated protein, without requiring direct protein interaction by the PROTAC warhead, and their subsequent degradation by the proteasome.

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