Extended Data Fig. 8: The degradation profiles of G4L-PROTACs in U2OS cells. | Nature Chemistry

Extended Data Fig. 8: The degradation profiles of G4L-PROTACs in U2OS cells.

From: Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras

Extended Data Fig. 8: The degradation profiles of G4L-PROTACs in U2OS cells.The alternative text for this image may have been generated using AI.

a, Volcano plots showing proteomic changes following treatment of U2Os cells with G4L-PROTACs compared to a negative control based on label-free quantification. Each point represents a protein (x-axis, log2 fold change; y-axis, −log10 P value), with significantly down-regulated G4-binding proteins (G4BPs) highlighted (FDR < 0.05). b, STRING-derived protein–protein interaction networks for significantly down-regulated proteins across selected G4L-PROTAC treatments, showing clustered functional modules (for example, chromatin regulators and transcription factors).

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