Extended Data Fig. 7: Subjective reports of pain within each pain stimulation site from patients in Study 1 and skin conductance responses from patients in Study 3.

(A) Overall pain ratings within each site on average across both conditions indicated strong within-site habituation effect. Trial 0 indicated the practice trial for each site and trials 1 & 2 were the experimental trials. (B) The patients showed stronger SCR to the control (red) than the thermedol treatment (blue) in Study 3. Panel A includes data from 24 patients in Study 1, and panel B includes data from 24 patients in Study 3. Error bars represent S.E.M.