Extended Data Fig. 8: Mediation analysis of the association between PRS and risky behaviour with GMV in dlPFC, putamen and hypothalamus (N = 12,675). | Nature Human Behaviour

Extended Data Fig. 8: Mediation analysis of the association between PRS and risky behaviour with GMV in dlPFC, putamen and hypothalamus (N = 12,675).

From: Genetic underpinnings of risky behaviour relate to altered neuroanatomy

Extended Data Fig. 8: Mediation analysis of the association between PRS and risky behaviour with GMV in dlPFC, putamen and hypothalamus (N = 12,675).The alternative text for this image may have been generated using AI.

The sum of all GMV differences in right dlPFC, putamen and hypothalamus (based on the activation masks from Fig 5A) mediated ~2.07% of the association between the PRS and risky behaviour. Arrows depict the direction of the structural equation modelling and do not imply causality.

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