Fig. 3: Striatal activity.
From: Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills
a, Striatal BOLD responses. A 3D reconstruction of the striatal masks used in the current experiment is surrounded by plots showing averaged BOLD activity for each mask in the different experimental conditions. An LMM run on these data showed higher striatal responses in the ReinfON than in the ReinfOFF condition, but no effect of tTISTYPE and no interaction (n = 24 participants). The data are represented as mean ± s.e. b, Whole-brain activity associated with the behavioural effect of tTIS80Hz on reinforcement motor learning. The correlation between tTIS-related modulation of striatal activity (tTIS80Hz–tTIS20Hz) and learning abilities in the ReinfON condition (n = 24) is shown. Significant clusters of correlation were found in the left putamen and bilateral caudate (t-contrast; uncorrected P = 0.001 at the voxel level; corrected cluster-based false discovery rate, P = 0.05). The lower panel shows individual robust linear regressions for the three significant regions highlighted in the whole-brain analysis.
