Extended Data Fig. 1: Replication of identifiability results at different doses of sevoflurane.
(a) Identifiability matrix between wakefulness and post-anaesthetic recovery. (b) Identifiability matrix between wakefulness and vol 2% sevoflurane anaesthesia (right). Entries along the diagonal, represent self-self similarity (correlation of FC patterns), whereas off-diagonal entries represent self-other similarity. (c) Self-self similarity is significantly higher between two conscious states, than between wakefulness and vol 2% sevoflurane. (d) The difference between self-self correlation and mean self-other correlation (differential identifiability) is significantly higher between two conscious states, than between wakefulness and vol 2% sevoflurane. (e) The regional distribution of contributions to identifiability (change in intra-class correlation coefficient) is plotted on the cortical surface. It is significantly spatially correlated with the corresponding map obtained with vol 3% sevoflurane: Spearman ρ = 0.61, pspin < 0.001, N = 200 regions. (f) Identifiability matrix between wakefulness and post-anaesthetic recovery. (g) Identifiability matrix between wakefulness and burst-suppression level of sevoflurane anaesthesia. (h) Self-self similarity is significantly higher between two conscious states, than between wakefulness and burst-suppression level of sevoflurane. (i) The difference between self-self correlation and mean self-other correlation (differential identifiability) is significantly higher between two conscious states, than between wakefulness and burst-suppression level of sevoflurane. (j) The regional distribution of contributions to identifiability (change in intra-class correlation coefficient) is plotted on the cortical surface. It is significantly spatially correlated with the corresponding map obtained with vol 3% sevoflurane: Spearman correlation ρ = 0.80, pspin < 0.001, N = 200 regions. N=15 human volunteers. Source data are provided as source data files.
