Extended Data Fig. 2: DBS-induced restoration of Integrated Information in the macaque brain mirrors the spatial topography of anaesthetic-induced disintegration and correlates with PVALB expression. | Nature Human Behaviour

Extended Data Fig. 2: DBS-induced restoration of Integrated Information in the macaque brain mirrors the spatial topography of anaesthetic-induced disintegration and correlates with PVALB expression.

From: Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains

Extended Data Fig. 2

(a) We observe a negative spatial correlation (Spearman’s rho, two-sided; significant against a spatial autocorrelation-preserving null distribution) between the cortical distribution of macaque PVALB gene expression, and the mean change in integrated information from comparing anaesthesia against baseline wakefulness in the macaque. Shading indicates 95% confidence intervals. (b) We observe a negative spatial correlation (Spearman’s rho, two-sided; significant against a spatial autocorrelation-preserving null distribution) between the cortical distribution of PVALB gene expression, and the mean change in integrated information from comparing anaesthesia against reawakening induced by CT stimulation. Shading indicates 95% confidence intervals. (c) We observe a negative spatial correlation (Spearman’s rho, two-sided; significant against a spatial autocorrelation-preserving null distribution) between the cortical distribution of PVALB gene expression, and the mean change in integrated information from comparing VT stimulation (which does not re-awaken the animal from anaesthesia) against CT stimulation. Shading indicates 95% confidence intervals. Credits: Macaque icon designed by Freepik.com. DBS and macaque thalamus illustrations adapted from Tasserie et al (2022), published under CC-BY license.

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