Extended Data Fig. 4: Integrated information across a bipartition of 6 channels.
(a) Human (n = 15) sevoflurane anaesthesia (Sevo) versus wakefulness (p < 0.001 from two-sided paired-samples t-test, FDR-corrected for multiple comparisons against Awake condition) and recovery (p < 0.001 from two-sided paired-samples t-test, FDR-corrected for multiple comparisons against Recovery condition). Box plots: central line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range. (b) Mouse wakefulness (n = 10) versus medetomidine-isoflurane (MedIso; n = 14) and halothane (Halo; n = 19) anaesthesia data. P-values are from two-sided independent-samples t-test, FDR-corrected for multiple comparisons against Awake condition. Box plots: central line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range. (c) Macaque wakefulness versus anaesthesia with propofol (Ppfl), sevoflurane (Sevo), and ketamine (Keta). N = 24 runs from 3 animals for Awake; 11 runs from 2 animals for Sevoflurane; 23 runs from 3 animals for Propofol; 22 runs from 3 animals for Ketamine anaesthesia. P-values are from linear mixed effects models (two-sided), FDR-corrected for multiple comparisons against Awake condition (see Methods). Box plots: central line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range. (d) Macaque DBS stimulation. N = 36 runs from 3 animals for Awake; 28 runs from 2 animals for anaesthesia (DBS-off); 31 runs from 2 animals for low amplitude centro-median thalamic DBS; 25 runs from 2 animals for high amplitude centro-median thalamic DBS; 18 runs from 1 animal for low amplitude ventrolateral thalamic DBS; 18 runs from 1 animal for high amplitude ventrolateral thalamic DBS. P-values are from linear mixed effects models (two-sided), FDR-corrected for multiple comparisons against propofol anaesthesia with no DBS (see Methods). Box plots: central line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range. Data-points with the same colour indicate the same animal. (e) Marmoset wakefulness versus anaesthesia with isoflurane (Iso), sevoflurane (Sevo) and propofol (Ppfl). N = 48 runs from 4 animals for each condition. P-values are from linear mixed effects models (two-sided), FDR-corrected for multiple comparisons against Awake condition (see Methods). Box plots: central line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range. Data-points with the same colour indicate the same animal. See Source Data for full statistical reporting. Credits: Human head icon from pixabay.com. Mouse icon designed by CraftStarters.com. Macaque icon designed by Freepik.com. DBS and macaque thalamus illustrations adapted from Tasserie et al (2022), published under CC-BY license. Marmoset icon from pixabay.com.
