Fig. 8: Macaque-specific biophysical model with stimulation of different thalamic nuclei reproduces the greater suitability of the central thalamus for restoring integrated information.
a, Illustration of thalamic ROIs and their inclusion in the DMF model; adapted from ref. 30, published under a CC-BY licence. Models based on the macaque anatomical connectivity, fitted to the empirical anaesthesia condition, are subjected to injection of excitatory current on the basis of the structural connectivity of the central thalamus (CT, red) and ventrolateral lateral thalamus (VT, green), obtained from diffusion-weighted MRI tractography of an independent sample of macaques. b, Simulated CT stimulation achieves significantly integrated information in brain dynamics than both no-stimulation (CT mean = 1.48 × 10−1 (s.d. = 1.27 × 10−2); No stim mean = 4.82 × 10−2 (s.d. = 5.67 × 10−3); t(80) = 45.88, P < 0.001 from independent-samples t-test (two-sided), Hedges g = 10.04, 95% CI [8.49, 12.70]) and VT stimulation (CT mean = 1.48 × 10−1 (s.d. = 1.27 × 10−2); VT mean = 1.35 × 10−1 (s.d. = 1.23 × 10−2); t(80) = 4.87, P < 0.001 from independent-samples t-test (two-sided), Hedges g = 1.07, 95% CI [0.64, 1.58]). N = 41 simulations for each condition. Boxplots: central line, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range. Credits: macaque DBS illustration adapted from ref. 30, published under a CC-BY licence.
