Extended Data Fig. 6: Intestinal tube morphogenesis: influence of collagen content in the support hydrogel.
From: Recapitulating macro-scale tissue self-organization through organoid bioprinting
Addition of collagen I increases the stiffness of the support hydrogel, limiting extensive budding of the tubes. Of note: when the gel is disrupted, budding can occur even at later time points also for initially stiffer hydrogels. Images are representative of n = 3 biologically independent experiments. Scale bars, 200 µm.
