Extended Data Fig. 4: Stability and pore crossing by LND-CDN vs. liposomes. | Nature Materials

Extended Data Fig. 4: Stability and pore crossing by LND-CDN vs. liposomes.

From: STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity

Extended Data Fig. 4: Stability and pore crossing by LND-CDN vs. liposomes.The alternative text for this image may have been generated using AI.

a, PEGylated LND with and without PEG molecules represented. b, PEGylated liposome without and with cross-sectional view of liposome interior. c, DLS analysis of LND size distributions before and after diffusion through 50 nm pore diameter membranes. d, LND-CDN or CDN-PEG-lipids were incubated with 10% serum in a dialysis cassette with a 5 KDa MWCO membrane, and STING activation bioactivity remaining in the sample (as assessed by activation of RAW-ISG reporter cells) was measured over time (n = 3 biologically independent samples per timepoint, mean±s.e.m. is plottted).

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