Extended Data Fig. 8: pSRC median fluorescent intensity for human ABC-DLBCL cell lines and PDX cells cultured in indicated conditions for 96 h.
a, pSRC median fluorescent intensity (MFI) in HBL1 (n = 7), OCI-LY3 (n = 4), and OCI-LY10 (n = 4) cell lines grown in REDV-functionalized hydrogel-based organoids with or without CD40L-expressing stromal cells. Two-tailed unpaired t-test (mean ± s.e.m.), where each dot is a hydrogel-based organoid. b, pSRC MFI in human ABC-DLBCL PDX cells grown in REDV-functionalized hydrogel-based organoids with CD40L-expressing stromal cells at different hydrogel polymer densities (stiffnesses). Two-tailed unpaired t-test (mean ± s.e.m., n = 3, where each dot is a hydrogel-based organoid). c, Effect of 1 μM CpG addition on pSRC MFI in OCI-LY3 and OCI-LY10 cells cultured for 96 h. Two-tailed unpaired t-test (mean ± s.e.m., n = 3, where each dot is a hydrogel-based organoid).
