Extended Data Fig. 5: KEGG enrichment analysis of CFs seeded on DECIPHER samples. | Nature Materials

Extended Data Fig. 5: KEGG enrichment analysis of CFs seeded on DECIPHER samples.

From: Hybrid hydrogel–extracellular matrix scaffolds identify biochemical and mechanical signatures of cardiac ageing

Extended Data Fig. 5: KEGG enrichment analysis of CFs seeded on DECIPHER samples.

Highlighted pathways of interest in young or aged CFs impacted by mechanical cues (Stiff vs. Soft, a) or ECM aging (Aged ECM vs. Young ECM, b) were graphed in the order of normalized enrichment score (NES) with color bar showing adjusted significance using Q-value (Two-sided Benjamini-Hochberg test). Significantly regulated pathways were marked with asterisks beside the pathway name: *Q < 0.05, **Q < 0.01, ***Q < 0.001. Bubble size indicates the number of genes differentially expressed in each pathway set.

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