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Albumin-coated lipid nanoparticles are effective delivery systems for mRNA vaccines

Nature Materials volume 24, pages 1692–1693 (2025)Cite this article

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An albumin-recruiting lipid nanoparticle formulation promotes lymphatic drainage while avoiding liver accumulation. In preclinical models of cancers and infectious diseases, mRNA vaccines prepared from this lipid nanoparticle platform elicit robust immune responses and achieve remarkable efficacy.

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Fig. 1: EB-LNP system and biodistribution pattern.

References

  1. Pateev, I. et al. Biodistribution of RNA vaccines and of their products: evidence from human and animal studies. Biomedicines 12, 59 (2023). A comprehensive review on the biodistribution of mRNA vaccines, highlighting the phenomenon of liver accumulation.

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This is a summary of: Feng, Y. et al. Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation. Nat. Mater. https://doi.org/10.1038/s41563-025-02284-w (2025).

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Albumin-coated lipid nanoparticles are effective delivery systems for mRNA vaccines. Nat. Mater. 24, 1692–1693 (2025). https://doi.org/10.1038/s41563-025-02285-9

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