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Making way for PEG alternatives

Nature Materials volume 24, pages 1682–1683 (2025)Cite this article

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Replacing traditional PEG-lipids in lipid nanoparticle formulations with zwitterionic polymer–lipid and brush polymer–lipid conjugates offers enhanced intracellular delivery and reduced immunogenicity, making them promising alternatives to PEGylated nanoparticles.

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Fig. 1: Strategies to address issues with PEGylated LNPs.

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Authors and Affiliations

  1. Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, La Jolla, CA, USA

    Weiwei Gao & Liangfang Zhang

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  1. Weiwei Gao
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  2. Liangfang Zhang
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Correspondence to Liangfang Zhang.

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Gao, W., Zhang, L. Making way for PEG alternatives. Nat. Mater. 24, 1682–1683 (2025). https://doi.org/10.1038/s41563-025-02381-w

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