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Improving preparedness for the next flu pandemic

Pandemic influenza remains the single greatest threat to global heath security. Efforts to increase our preparedness, by improving predictions of viral emergence, spread and disease severity, by targeting reduced transmission and improved vaccination and by mitigating health impacts in low- and middle-income countries, should receive renewed urgency.

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Fig. 1: Detected human infections with avian and swine influenza viruses.

References

  1. FAOSTAT: Live Animals (FAO); http://www.fao.org/faostat/en/#data/QA

  2. WHO. Wkly Epidemiol. Rec. 92, 129–144 (2017).

    Google Scholar 

  3. Notice announcing the removal of the funding pause for gain-of-function research projects. NIH (19 December 2017).

  4. Pybus, O. G., Tatem, A. J. & Lemey, P. Proc. Biol. Sci. 282, 20142878 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Lipsitch, M. et al. Biosecur. Bioterror. 9, 89–115 (2011).

    PubMed  PubMed Central  Google Scholar 

  6. Lessler, J., Edmunds, W. J., Halloran, M. E., Hollingsworth, T. D. & Lloyd, A. L. Epidemics 10, 78–82 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Browne, A., Ahmad, S. S., Beck, C. R. & Nguyen-Van-Tam, J. S. J. Travel. Med. 23, tav002 (2016).

    Article  PubMed  Google Scholar 

  8. Priest, P. C., Jennings, L. C., Duncan, A. R., Brunton, C. R. & Baker, M. G. Am. J. Public Health 103, 1412–1418 (2015).

    Article  Google Scholar 

  9. Cowling, B. J. et al. BMC Infect. Dis. 10, 8 (2010).

    Article  Google Scholar 

  10. Fumanelli, L., Ajelli, M., Merler, S., Ferguson, N. M. & Cauchemez, S. PLoS Comput. Biol. 12, e1004681 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Rashid, H. et al. Paediatr. Respir. Rev. 16, 119–126 (2015).

    PubMed  Google Scholar 

  12. Wong, V. W., Cowling, B. J. & Aiello, A. E. Epidemiol. Infect. 142, 922–932 (2014).

    Article  CAS  PubMed  Google Scholar 

  13. Okoli, G. N., Otete, H. E., Beck, C. R. & Nguyen-Van-Tam, J. S. PLoS ONE 9, e113633 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Universal Health Coverage (WHO); http://apps.who.int/gho/cabinet/uhc.jsp

  15. Dawood, F. S. et al. Lancet Infect. Dis. 12, 687–695 (2012).

    Article  PubMed  Google Scholar 

  16. Nair, H. et al. Lancet 378, 1917–1930 (2011).

    Article  PubMed  Google Scholar 

  17. Cohen, C. et al. Clin. Infect. Dis. 51, 1362–1369 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  18. Yu, H. et al. Influenza Other Respir. Viruses 7, 1350–1360 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  19. Chadha, M. S. et al. PLoS ONE 8, e55918 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. WHO Model Lists of Essential Medicines (WHO, 2017); http://www.who.int/medicines/publications/essentialmedicines/en/

  21. The I-SPY2 Trial (I-SPY); https://www.ispytrials.org/i-spy-platform/i-spy2

  22. Chien, Y. W., Klugman, K. P. & Morens, D. M. N. Engl. J. Med. 361, 2582–2583 (2009).

    Article  PubMed  Google Scholar 

  23. Campbell, H. et al. PLoS Med. 10, e1001421 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  24. Duke, T. et al. Int. J. Tuberc. Lung Dis. 14, 1362–1368 (2010).

    CAS  PubMed  Google Scholar 

  25. Madhi, S. A. & Klugman, K. P., Vaccine Trialist Group. Nat. Med. 10, 811–813 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Caldwell, R., Roberts, C. S., An, Z., Chen, C. I. & Wang, B. BMC Infect. Dis. 15, 284 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  27. Casey, R. M. et al. MMWR Morb. Mortal Wkly Rep. 65, 1270–1273 (2016).

    Article  PubMed  Google Scholar 

  28. McLean, K. A., Goldin, S., Nannei, C., Sparrow, E. & Torelli, G. Vaccine 34, 5410–5413 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Peter Horby.

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Horby, P. Improving preparedness for the next flu pandemic. Nat Microbiol 3, 848–850 (2018). https://doi.org/10.1038/s41564-018-0206-7

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