Extended Data Fig. 9: MAC13772 is efficacious against A. baumannii in a systemic infection with human biotin levels. | Nature Microbiology

Extended Data Fig. 9: MAC13772 is efficacious against A. baumannii in a systemic infection with human biotin levels.

From: Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens

Extended Data Fig. 9

Bacterial load of A. baumannii in the blood, spleen, kidneys, liver, and lungs following a systemic infection with (a) standard biotin levels and (b) human biotin levels, treated with MAC13772 (15 mg/kg). Mice were pretreated with streptavidin (2 mg/kg) 1-hour prior infection and treated with MAC13772 (15 mg/kg) 1-hour following infection. Groups were analyzed with an unpaired two-tailed t-test and corrected for multiple comparisons with a Holm-Sidak test, * indicates a p<0.01. (c) Time course of plasma concentrations of MAC13772 in male (black) and female (grey) Sprague Dawley rats, after intravenous administration. Each data point represents the mean ± s.d. concentration from n=3 rats, the dotted line indicates the limit of quantification (LOQ).

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