Extended Data Fig. 3: Universal IDTS are required for replication of L. pneumophila strains 130b and Paris in amoebae.
The wild type (WT) and indicated IDTS null mutant strains were used to challenge amoebae and bacterial growth, based on recovered colony forming units (cfus) on solid media from lysed host cells, was assessed after 24 hours. Plotted is the total bacterial yield 24 hours post infection (hpi) normalized to the WT strain by the number of intracellular bacteria 1–2 hpi. Data are the mean ± standard deviation of 2–3 biological replicates, each generated from 3 technical replicates, *P<0.02, 1-way ANOVA, relative to the WT strain (Source Data for Extended Data Fig. 3).
