Extended Data Fig. 1: Purification of various EcoR124I complexes.

a-c, Elution profiles of SEC runs on Superdex 200 10/300 column and SDS-PAGE results of indicated fractions for M₂S₁ MTase and R₂M₂S₁ holoenzyme (a), M₂S₁ bound to DNA/ArdA (b), and R₂M₂S₁ bound to DNA/Ocr/ArdA (c). Experiments were performed three times independently with similar results.

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