Extended Data Fig. 6: Steady-state analyses of BLI binding saturation and sensitization of NiV L to GHP-88309.
From: Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase
Steady-state analyses of BLI binding saturation and sensitization of NiV L to GHP-88309. a, Concentration-dependent steady-state BLI sensor response signals were plotted for the different MeV L1708 samples (standard (WT) or carrying resistance mutations as indicated) to probe whether saturation of binding was reached. b, NiV minigenome assays to test inhibitory activity of GHP-88309 against standard NiV RdRP and NiV RdRP harboring an LH1165Y point mutation. Symbols represent biological repeats, lines are derived from 4-parameter variable slope regression modeling, and active concentrations (EC50 and EC90 if applicable) are shown with 95% CIs.
