Extended Data Fig. 10: Mapping of RSV L capping blocker and AZ-27 resistance hotspots. | Nature Microbiology

Extended Data Fig. 10: Mapping of RSV L capping blocker and AZ-27 resistance hotspots.

From: Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase

Extended Data Fig. 10

Mapping of RSV L capping blocker and AZ-27 resistance hotspots. Analogous positions of resistance mutations against the RSV L capping inhibitor compound C (E1269D and I1381S; magenta spheres) and initiation blocker AZ-27 (Y1631; orange spheres) are projected onto an HPIV3 L homology model when locatable. Resistance mutations against the capping inhibitor are proximal to conserved PRNTase motifs (blue spheres) and distal to GHP-88309 resistance mutations (red spheres). The RdRP, connector, and capping domains are color-coded as in Fig. 2a. The HPIV3 L homology model is based on the coordinates reported for HPIV5 L (PDB: 6v85).

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