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MICROBIOME

Microbiome–diet interactions drive antibiotic efficacy

Nature Microbiology volume 6, pages 824–825 (2021)Cite this article

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A high-fat diet causes gut microbiota dysbiosis and depletion of the microbial metabolite indole-3-acetic acid in a murine model, resulting in decreased antibiotic efficacy against bacterial infections.

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Fig. 1: The gut microbiota metabolome influences infection outcomes in different nutritional environments.

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Acknowledgements

We acknowledge the Portuguese national funding agency Fundação para a Ciência e Tecnologia (FCT) for individual grant nos. IF/00831/2015, PD/BD/106000/2014 and SFRH/BPD/116806/2016 to K.B.X., R.A.O. and V.C., respectively, and the project PTDC/BIA‐MIC/6990/2020.

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  1. Instituto Gulbenkian de Ciência, Oeiras, Portugal

    Rita A. Oliveira, Vitor Cabral & Karina B. Xavier

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  1. Rita A. Oliveira
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  2. Vitor Cabral
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  3. Karina B. Xavier
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Correspondence to Karina B. Xavier.

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The authors declare no competing interests.

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Oliveira, R.A., Cabral, V. & Xavier, K.B. Microbiome–diet interactions drive antibiotic efficacy. Nat Microbiol 6, 824–825 (2021). https://doi.org/10.1038/s41564-021-00926-8

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