Extended Data Fig. 6: CF and non-CF individuals are well connected within the transmission network.
From: Dissemination of Mycobacterium abscessus via global transmission networks
Network connectivity scores were calculated from the transmission calculated at a cutoff of 38 SNPs presented in Fig. 4D. (a) The number of connections exhibited by each individual in the network was calculated and split into CF and non-CF individuals. The mean number of connections exhibited by an individual with the corresponding CF status is plotted. (b) Each connection in the transmission network was given a weighting based on the minimum SNP distance between isolates from the corresponding individuals, calculated as ‘39 – minimum SNP distance’. Therefore linkages representing fewer SNPs are given a higher weighting, the maximum weighting is 38 if isolates from two individuals differ by 0 SNPs and linkages at 38 SNPs have a weighting of 1. The weighted linkages of all individuals with the corresponding CF status were summed and divided by the number of individuals with that status. (c) Connections in the transmission network were divided into three categories based on the CF status of the two linked individuals: CF < - >CF, CF < - >non-CF, non-CF < - >non-CF. Linkages were weighted as in (b). All weighted linkages within each type of linkage were summed and divided by the total number of potential linkages between individuals with the corresponding CF status.
