Extended Data Fig. 8: DCCs 1-4 exhibit a significant temporal signal.
From: Dissemination of Mycobacterium abscessus via global transmission networks
Date randomization test for DCCs 1-4. Points show median values and error bars the 95% HPD (number of samples from the posterior distribution: DCC1 informed, DCC1 uniform, DCC2 informed, DCC3 informed, DCC3 uniform = 2255 each, DCC4 informed, DCC4 uniform, all date randomisations = 2703 each, DCC2 uniform = 4506). The temporal evolutionary history of each DCC was reconstructed with an informed prior on the substitution rate based on root-to-tip analysis and a uniform prior (see methods). The results from these priors matched closely in all cases. We compared the tree root date and substitution rate inferences from these priors with ten date randomization runs where the sample collection dates were randomly assigned to sequences and the temporal history reconstructed. In all cases, the posterior distributions inferred with the real dates were highly different from those inferred with the date randomizations, suggesting the existence of a significant temporal signal within each DCC.
