Extended Data Fig. 5: GWAS for variants associated with clinical isolates and triazole resistance.
(a & c) Q–Q plots for association with isolate source (a; clinical vs. environmental) and triazole resistance (c; resistance to one or more triazole vs. susceptible to all examined; c). Four software were utilized: EMMAX (top, left), GEMMA (top, right), treeWAS (bottom, left) and ECAT (bottom, right). The resulting Q–Q plots were used to identify the tool that produced outputs where the expected p-value distribution (x-axis) best matched the observed p-values (y-axis). (b) Venn diagram showing the gene overlap between GWAS for all clinical strains relative to environmental and significant genes specific to acute and chronic disease. (d) Venn diagram showing the gene overlap for association with triazole resistance when minor allele frequencies (MAF) of 0.01 and MAF 0.05 were used.
