Extended Data Fig. 4: Discriminant analysis of principle components of 300 A. fumigatus isolates.

(a-c) Number of clusters vs. Bayesian information criteria (BIC) was used to assess the best supported number of genetic clusters for the dataset. The input for analysis was either (a) a non-gapped core nucleotide alignment from 5,830 single-copy orthologous genes (b) a gene count matrix from orthogroup-based clustering of pansequences or (c) or whole-genome SNV data with of positions with zero genomic coverage in any isolate in the dataset excluded.