Extended Data Fig. 2: Stimulation index for SARS-CoV-2-spike specific T cells. | Nature Microbiology

Extended Data Fig. 2: Stimulation index for SARS-CoV-2-spike specific T cells.

From: Induction of robust cellular and humoral immunity against SARS-CoV-2 after a third dose of BNT162b2 vaccine in previously unresponsive older adults

Extended Data Fig. 2

(a) Percentages of SARS-CoV-2 spike-specific CD4 T cells were analyzed in 51 donors aged >80 years (blue symbols) and 45 donors aged 20–42 plus one 53 years old (yellow symbols) 21 d after the first and 14 d after the second BNT162b2 (Pfizer-Biontech) vaccination (day 35). (b) Five low-/non-responders (red triangles) received a third BNT162b2 dose 16 weeks (W16) after the first vaccination and T cell responses were analyzed in week 18 (W18). Stimulation index (SI) was obtained by dividing the percentages of spike-reactive T cells and those activated under control conditions. Each symbol represents one donor. Horizontal lines indicate medians. P values determined by two-tailed Mann-Whitney test (a) or one-tailed Wilcoxon matched-pairs signed rank test (b). Time p.p.v., Time post primary vaccination.

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