Fig. 1: CD8+ and CD4+ T-cell responses targeting conserved and mutated epitopes in Omicron/B.1.1.529, BA.1.
From: SARS-CoV-2-specific T-cell epitope repertoire in convalescent and mRNA-vaccinated individuals
a, Percentages of CD8+ T-cell responses to previously described optimal CD8+ T-cell epitopes within the complete WT SARS-CoV-2 variant B proteome normalized to the HLA allotype. b, Number and location of spike-specific CD8+ (top) and CD4+ (bottom) T-cell responses to OLPs of the spike protein detectable in SARS-CoV-2 convalescent individuals and vaccinees after two doses of Pfizer/BioNTech mRNA vaccine are depicted. The heatmaps depict the compiled data of tested individuals. Epitopes with amino acid sequence variations in Omicron/B.1.1.529, BA.1 are marked in red. The number of tested individuals (per HLA allotype and in total) and percentage of total T-cell responses targeting variant epitopes are indicated. WT: epitope conserved between WT SARS-CoV-2 variant B and Omicron/B.1.1.529; Mut: epitope mutated in Omicron/B.1.1.529 compared to WT variant B SARS-CoV-2.
