Extended Data Fig. 3: Overview of actual and potential biosynthetic diversity of bacterial kingdom, compared at REDgroup level.
From: Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes
Extended Data Fig. 3 is interactive and can be accessed online on iTOL: https://itol.embl.de/shared/1B6W5n9MixSdJ. GTDB bacterial tree up to REDgroup level (for more details see Methods - REDgroup definition), colour-coded by phylum, decorated with barplots of actual (orange) and potential (purple) Gene Cluster Families (GCFs) as defined by BiG-SLiCE (T = 0.4). Potential GCFs were computed by rarefaction analyses (for more details see Results - Well known and less popular taxa as sources of biosynthetic diversity). REDgroups names are displayed around the tree as leaf node labels; hovering over them provides further taxonomic information (for full REDgroup metadata see Supplementary Table 1). Phyla known to be enriched in NP producers are immediately visible (Actinobacteriota, Protobacteriota), with the most promising groups coming from the Actinobacteriota phylum (the highest peak belongs to a REDgroup containing Streptomyces strains). Simultaneously, within the underexplored phyla, there seems to be notable biosynthetic diversity and potential. This Figure is meant to be explored by zooming in and out, searching for keywords and visualizing different kinds of information by switching between Tree Views. Any other attempt at modification (for example turning datasets on and off) may result in an unreadable graph.
