Fig. 5: Proposed model for 76E1 neutralization of SARS-CoV-2.
From: Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2
The closed RBD in the prefusion S trimer could not recognize the hACE2 receptor of the host cell. The receptor binding process induces obvious conformational change of the S trimer, especially for the exposure of the fusion peptide (FP) and the S2’ site. Once the fusion peptide and S2’ sites are exposed, 76E1 will immediately target the sites and inhibit S2’ cleavage, thus avoiding S2’ fragment refolding and blocking the virus–host cell membrane fusion. Different from previously reported RBD mAb CB6 and S2 stem helix mAbs S2P6 and B6, 76E1 represents a new class of antibody against SARS-CoV-2.
