Extended Data Fig. 5: A family of dGTPases in defense islands.
From: Bacteria deplete deoxynucleotides to defend against bacteriophage infection
(A) Representative instances of dGTPase genes (in orange) and their genomic neighborhoods. Colors and annotations are as in Supplementary Fig. S1A. M, S and R designations within type I RM operon genes represent the methylase, specificity, and restriction subunits, respectively. (B) Superposition of the AlphaFold predicted structural model of Sp-dGTPase (orange) aligned with the N-terminus of the human SAMHD1 (PDB: 4bzb, chain D) (grey). Mg2+ ion is depicted as a yellow sphere. SAMHD1 catalytic site is depicted with grey sticks, and is bound to the dGTP ligand. Alignment was performed by PDBeFOLD, with a Q score = 0.11, Z score = 5.5 and RMSD = 2.89 Å between the predicted dGTPase AlfaFold2 model and the human SAMHD1. The presented structural alignment includes residues 23–161 & 248–452 from the dGTPase AlphaFold model, aligned to residues 129–275 & 299–439 of the human SAMHD1 structure.
