Extended Data Fig. 3: Metagenomic prevalence of BT0413-BT0416.
From: A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria
a, Metagenomic prevalence of genes across the collections available in the curatedMetagenomicData program. Each row of the heat map represents a different collection, with each column representing an individual gene. The full cluster annotation is the percent of samples in each collection that possess all 4 genes (BT0413-BT0416). b, IsoalloLCA-3-sulfate was produced by species from the Bacteroidetes phylum containing a homolog for BtSULT (black text) and was not produced by Bacteroides species (Alistipes indistinctus DSM 22520, Butyricimonas synergistica DSM 23225) and other bacteria (E. coli Nissle 1917, C. scindens VPI 12708, and E. lenta 14A) that lack a BT0416 homolog (blue text) (n = 3 biological replicates per group, data are mean ± SEM).
