Extended Data Fig. 6: Mutation rates of Bt81 x H99 crg1Δ F1 progeny. | Nature Microbiology

Extended Data Fig. 6: Mutation rates of Bt81 x H99 crg1Δ F1 progeny.

From: Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans

Extended Data Fig. 6

Fluctuation analysis was used to quantify the mutation rates of the indicated strains on YPD + rapamycin + FK506 medium (y-axis) – sorted smallest to largest, left to right – for F1 progeny and the parental strains, H99 crg1Δα and Bt81 (x-axis). Heights of bars indicate the mean mutation rate and error bars represent 95% confidence intervals. Mutation rates represent the number of mutations per cell per generation. Inheritance of the Bt81 znf3 allele or H99 crg1Δ ZNF3 allele in the F1 progeny is indicated above mutation rates. Fluctuation analysis was conducted once for all strains, with n = 10 biologically independent cultures per strain.

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