Fig. 1: P2G3 is a human mAb with potent activity. | Nature Microbiology

Fig. 1: P2G3 is a human mAb with potent activity.

From: Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

Fig. 1

a, Blocking activity of individual and combinations of anti-spike mAbs in a biochemical spike-ACE2 surrogate neutralization assay using Omicron BA.1, BA.1.1 encoding the R346K mutation and BA.2 variant spike trimer proteins. Mean ± s.e.m. are shown. b, Comparative spike-ACE2 blocking activity of P2G3, P5C3 and the P2G3/P5C3 mix compared to a panel of benchmark anti-SARS-CoV-2 mAbs. P2G3 and P5C3 used in these studies and throughout the manuscript contain the LS mutation in the Fc domain (M428L/N434S), previously demonstrated to confer an extended half-life in vivo. Data presented are biological replicates with n = 8, 7, 8, 8, 7, 5, 6, 7 and 4 for mAbs in order of appearance in the legend.

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