Extended Data Fig. 9: Angle of attack of Fabs for authorized and clinically advanced anti-SARS-CoV-2 mAbs modelled to the Omicron Spike trimer. | Nature Microbiology

Extended Data Fig. 9: Angle of attack of Fabs for authorized and clinically advanced anti-SARS-CoV-2 mAbs modelled to the Omicron Spike trimer.

From: Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

Extended Data Fig. 9: Angle of attack of Fabs for authorized and clinically advanced anti-SARS-CoV-2 mAbs modelled to the Omicron Spike trimer.The alternative text for this image may have been generated using AI.

Model of Fabs for Class 3 antibodies, REGN10987, AZD1061 and S309/Sotrovimab binding each of the RBD protomers for the full Omicron trimer. Trimers are shown from multiple perspectives to visualize the different angles of attack the Fabs have depending on the Spike protomer. a) REGN10987 Fab bind to the green RBD-up conformation but modelled REGN10987 Fab bound to either the RBD-down of the orange or blue protomer would clash sterically with the adjacent blue RBD-down or green RBD-up protomers, respectively. Together it is predicted REGN10987 is able to bind only RBD-up. b) AZD1061 is predicted to bind the RBD-up form and RBD-down form of the blue protomer but AZD1061 Fab modelled binding to the RBD-down of the orange protomer would potentially clash with the adjacent green RBD-up. c) S309/Sotrovimab is able to bind all RBDs simultaneously as shown for P2G3. d) Angle of attack of Fabs to the RBD is defined as the line connecting the centroid of the Fab to the centroid of the surface area of the RBD that the Fabs bury.

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