Extended Data Fig. 2: P2G3 retains neutralizing activity against R346K Spike-coated pseudoviruses and all SARS-CoV-2 variants in a live virus cytopathic effect assay.
Neutralization of lentiviral particles pseudotyped with: a) SARS-CoV-2 Spike encoding R346K mutation and the D614G substitution that became dominant early in the pandemic and b) Omicron BA1.1 with the R346K substitution in a 293T-ACE2 infection assay. Panels a and b represent triplicates for all mAbs tested with the exception of AZD8895 and AZD1061 that were tested as duplicates in a. c) P2G3 evaluated in live virus cytopathic effect neutralization assays with the original 2019-nCoV and Alpha, Beta, Gamma, Delta and Omicron BA.1 variants of concern with n = 6, 4, 4, 4, 6 and 6 replicates shown, respectively. Mean values ± SEM are shown.
