Extended Data Fig. 6: Impact of antimicrobial treatment on GPSCs and lineages classified by PBP gene type of Li et al., 2016.

(a) The proportion of lineages made up of each GPSC after treatment (red) and in the absence of treatment (blue). Only those GPSCs that are present at a prevalence of at least 1% in the full data set are included. (b) The log odds ratio of clearance following treatment for 1,848 lineages containing previously classified PBP genes in Li et al., 2016 (left). Those in red are significantly more likely to persist following antimicrobial treatment whilst those in blue are likely to be eliminated. Error bars indicate the standard deviation of the coefficient point estimate in the GLM. The corresponding distribution of MIC profiles for lineages found to contain these PBP genes in Li et al. is given to the right. The median and interquartile range is given by the horizontal lines with the whiskers indicating the largest and smallest values excluding those outside 1.5 times the interquartile range.