Extended Data Fig. 2: Sequence alignment of the Cas7-11 orthologs.
From: Structure and function of a bacterial type III-E CRISPR–Cas7-11 complex
The residues crucial for the pre-crRNA maturation are indicated by green dots. The active-site residues in Cas7.2 and Cas7.3 are indicated by pink and cyan triangles, respectively. The residues critical for crRNA recognition and target RNA cleavage are indicated by orange stars. CjcCas7-11, Cas7-11 from Candidatus Jettenia caeni; CbfCas7-11, Cas7-11 from Candidatus Brocadia fulgida; SstCas7-11, Cas7-11 from Sorted cell/s from Southern Trench hydrothermal vent microbial mat; HsmCas7-11, Cas7-11 from Hydrothermal sediment microbial communities from Guaymas Basin; DsbaCas7-11, Cas7-11 from Desulfobactera ceae bacterium.
