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Modelling human immune responses using microbial exposures in rodents

Nature Microbiology volume 8, pages 363–366 (2023)Cite this article

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The extent and diversity of exposures to microbial stimuli have a crucial role in regulating the capacity of a host to mount an immune response to a challenge, such as vaccination, making exposure history an important factor to optimize in rodent models.

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Fig. 1: Rodent models using microbial exposure to enhance relevance to human immune responses.

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Acknowledgements

M.T.B. is supported by National Institutes of Health (NIH) funding R01OD024917, R01AI141716 and R01AI139314. The content is solely the responsibility of the author and does not necessarily represent the official views of the NIH.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA

    Yuhao Li & Megan T. Baldridge

  2. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA

    Megan T. Baldridge

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  1. Yuhao Li
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  2. Megan T. Baldridge
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Correspondence to Megan T. Baldridge.

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Nature Microbiology thanks the anonymous reviewers for their contribution to the peer review of this work.

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Li, Y., Baldridge, M.T. Modelling human immune responses using microbial exposures in rodents. Nat Microbiol 8, 363–366 (2023). https://doi.org/10.1038/s41564-023-01334-w

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