Extended Data Fig. 7: Sample-to-sample co-abundance of phages in the virome and host-bacteria in the metagenome.
From: Expanding known viral diversity in the healthy infant gut
Correlations between host bacterial relative genus abundances in the metagenomes with aggregate relative abundances for phages predicted to infect those host genera in the virome, compared across all children. A) Volcano plot showing how all significant correlations between phage-host pairs were positive (ρ > 0; n = 87 genera, Spearman’s correlation tests, two-sided P values). B) The distribution of these correlation values was significantly higher than zero (One-sample Wilcoxon test, two-sided P = 2.4·10-12, n = 87, right side), whereas random non-matched phage-host pairs were centered around zero (left side). C) These correlations were positive regardless of phage lifestyle (one-sample Wilcoxon tests with two-sided P values), and D) stood out against the background of all genus combinations tested (same data shown in panel B, diagonal is matched phage-host pairs and off-diagonal are non-matched pairs). Boxplots demonstrate median, middle line; lower and upper quartile, box bounds; and most extreme observations within 1.5 x interquartile range above/below box, whiskers. All individual data points are overlaid on the boxplots.
