Fig. 5: Effect of zinc chelation on CCR5+/– and α4β7+/– Th1 and Th2 cells.
From: Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques
a–d, Comparison of expressions of CCR5 and α4β7 markers in Th1 and Th2 memory cells in the absence or presence of zinc chelator and stimuli in the vaccine+SAMT-247 group (n = 4) and vaccine group (n = 2). e–h, Radar plots comparing different expressions of cytokines by different subsets of Th1 and Th2 cells from vaccinated animals at week 17 in the absence or presence of stimulation and zinc chelator (n = 6). Data shown in a–h were analysed with the two-tailed Wilcoxon signed-rank test. Horizontal and vertical bars denote mean and standard deviation. The radar plot represents the mean percentage value of cytokine responses. Solid lines represent the absence of zinc chelator and dashed lines represent the presence of zinc chelator.
