Fig. 6: Model for SAMT-247 modulation of mucosal immune responses.
From: Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques
Vaccination-induced ADCC results in apoptosis of SIV-infected cells, which in turn are cleared by efferocytes to avoid inflammation and preserve tissue homeostasis. Vaccine-induced IL-10 expression in CD14+ monocytes further augments efferocytosis. Vaccine-induced NKp44+ cells produce the IL-17 cytokine that maintains mucosal epithelium integrity. All of these protective effector responses were enhanced dramatically in the vaccine + SAMT-247 group, increasing protection from SIVmac251 acquisition. The scheme is adapted from Bissa et al.15.
