Fig. 3: Genetic crosses and BSA reveal two QTL after CQ selection. | Nature Microbiology

Fig. 3: Genetic crosses and BSA reveal two QTL after CQ selection.

From: Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

Fig. 3: Genetic crosses and BSA reveal two QTL after CQ selection.The alternative text for this image may have been generated using AI.

a, Allele frequency plots across the genome before and after CQ treatment. Lines with the same colour indicate results from technical replicates. b, QTLs identified using the G′ approach. Lines with the same colour indicate results from technical replicates. a and b include results from BSA with 48 h CQ treatment with samples collected at day 4. For the complete BSA from different collection timepoints and drug treatment duration under different CQ concentrations, see Supplementary Figs. 3 and 4. c, Fine mapping of the chr. 6 QTL. The 95% confidence intervals (CIs) were calculated from the 250 nM CQ treated samples, including data from different collection time points (day 4 for 48 h CQ treatment and day 5 for 96 h CQ treatment), pools (pool 1 and pool 2), and drug treatment duration (48 h and 96 h). Light cyan shadow shows boundaries of the merged CIs of all the QTLs. Each line indicates one QTL; black dashed line indicates threshold for QTL detection (G′ = 20). The vertical red dashed line indicates pfaat1 location.

Back to article page