Fig. 6: A. muciniphila exacerbates type-2 immune responses during food allergy under fibre deprivation in a gnotobiotic mouse model.

a, Relative abundance of microbial strains assessed from pre- and post-sensitization by phylotype-specific qPCR for both 14SM-colonized (left and middle) and 13SM-colonized (right) mice. b,c, Blinded symptom scores (b) and core body temperature (c) acquired after OVA challenge in mice fed an FR (green) or an FF (red) diet (n = 3–9, at least two independent experiments, Kruskal–Wallis test with unadjusted P values, non-significant after adjustment using the Benjamini–Hochberg method (b) or two-way ANOVA (c), with P values adjusted using the Benjamini–Hochberg method between FR vs FF among OVA-CTX mice). d–f, Frequencies of immune cell populations identified with mass cytometry and FlowSOM analysis (d,e, n = 5–10, two independent experiments, two-way ANOVA, non-adjusted individual P values, bolded P values remain below 0.05 after adjustment using the Benjamini–Hochberg method) and of eosinophils as identified by flow cytometry and FlowJo analysis (f, n = 3–7, two-way ANOVA, P values adjusted using the Benjamini–Hochberg method) in the colonic lamina propria of mice fed an FR or an FF diet. g, Frequencies of faecal IgE-coated bacteria at the end of the experiment (n = 4–8, two independent experiments, two-way ANOVA, P values adjusted using the Benjamini–Hochberg method). All dot plots are represented with mean ± s.e.m.