Extended Data Fig. 3: Data integration.
From: Genome-wide chromatin interaction map for Trypanosoma cruzi
Normalized Hi-C interaction frequencies of chromosome 10 of T. cruzi displayed as a two-dimensional heatmap at 10 kb resolution. Chromatin Folding Domains (CFDs) identified using TADtools are indicated as triangles on the Hi-C map. Insulation score values were calculated using FAN-C and the black horizontal dashes represent the local minima of the insulation score, indicatives of the domain boundaries. RNA expression across the chromosome is depicted as coverage plots using a bin size of 10 bp. For each condition, two biological replicates are plotted. A: amastigotes; E: epimastigote; and T: trypomastigote forms. Vertical gray bars indicate the position of all well-positioned nucleosomes. Polycistronic Transcription Units (PTUs). This is a core chromosome as the core compartment comprises the entire chromosome. Some disruptive genes present in this chromosome are indicated as yellow arrows. Zero coverage regions (\(\ge\) 500 bp length) are shown as black vertical lines. Low coverage regions were determined considering all transcriptomes and are represented as blue blocks.
