Extended Data Fig. 7: Drug interaction fingerprint recapitulates their functional and chemical classes.
From: Systematic analysis of drug combinations against Gram-positive bacteria
a, Drugs clustered according to their interactions with all other drugs in main screen. For each drug, quartile-based Bliss interaction scores (Methods) with all the other drugs (n = 65) in all four strains (x-axis) are considered; drug interaction fingerprints are then clustered according to their cosine similarity. All interaction cumulative scores are considered, regardless of their significance. Clusters enriched in drugs belonging to the same classes, targeting the same processes, and/or chemically similar, are highlighted. Negative, positive and neutral Bliss scores are depicted in shades of green, yellow, and in white, respectively. Combinations that were not tested in a given strain are in grey. b, Drug clustering according to their chemical structure similarity (Methods). In both panels, drugs are coloured according to their targeted cellular process (colour code as in Fig. 1).
