Fig. 4: Depletion of PfAP2-P increases chromatin accessibility.
From: DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages
a, The most significantly enriched motif bound by PfAP2-P at 16 h.p.i. b,c, The top most (b) and the second most (c) significantly enriched motifs bound by PfAP2-P at 40 h.p.i. d, The most enriched motif (c) at 40 h.p.i. is similar to the PfAP2-I binding motif. e, The numbers of genes with promoters bound by PfAP2-P at either 16 h.p.i., 40 h.p.i. or both. f,g, Genomic regions uniquely bound by PfAP2-P at 16 h.p.i. (f) or at both 16 and 40 h.p.i. (g). x axis shows the genomic position and numbers on the right show the enrichment score. h,i, Label-free quantitative proteomic analysis of P. falciparum proteins enriched in PfAP2-P immunoprecipitates at 16 h.p.i. (h) and 40 h.p.i. (i). j, Chromatin contact count heatmap of chromosome 7 at 16 h.p.i. (first three) and 40 h.p.i. (last three) for the control and Δpfap2-p parasites, as well as the \({\log }_{2}\) fold change in interactions (third and sixth panels from left) between control and Δpfap2-p parasites. Blue indicates a loss of interactions and red indicates an increase of interactions of Δpfap2-p over control (WT). Chr, chromosome.
