Fig. 3: Vaginal microbiome structure of the Isala and VALENCIA cohorts.
From: A citizen-science-enabled catalogue of the vaginal microbiome and associated factors
a–d, t-SNE plot of microbiome samples in the Isala study; samples are coloured by the 13 CSTs as defined by VALENCIA (a)10. CST I—L. crispatus-dominated (A, high relative abundance; B, lower relative abundance), CST II—L. gasseri-dominated, CST III—L. iners-dominated (A, high relative abundance; B, lower relative abundance) and CST V—L. jensenii-dominated. CST IV-A—Candidatus Lachnocurva vaginae (BVAB1, identified up to the genus level as EU728721_g in the Isala data) with low abundance of G. vaginalis. CST IV-B—G. vaginalis with low relative abundance of Ca. L. vaginae. CST IV-C0—Prevotella, CST IV-C1—Streptococcus, CST IV-C2—Enterococcus-dominated, CST IV-C3—Bifidobacterium-dominated and CST IV-C4—Staphylococcus-dominated. Samples are coloured by the most abundant (sub)genus (b). Samples are coloured by the second most abundant (sub)genus (c). Samples are coloured by the largest relative abundance level in each sample (d). e–h, t-SNE plot of microbiome samples of the VALENCIA dataset (multi-temporal samples per participant included), coloured by the CSTs (e). Samples of the VALENCIA dataset coloured by the most dominant genus (f), by the second most dominant genus (g) and by the largest relative abundance level in each sample (h). In all plots, the grey dashed outlines indicate the ‘bridge’ regions samples dominated by L. iners and L. crispatus.
