Table 2 Antimalarial drug resistance genetic marker frequencies for the combined 196 samples (109 leucodepleted VB and 87 DBS samples)
Gene | SNP | Accra VB, n (%), Total N = 39 | Navrongo VB, n (%), Total N = 70 | Navrongo DBS, n (%), Total N = 87 | All, n (%), Total N = 196 |
|---|---|---|---|---|---|
crt | K76T | 1 (2.6%) | 0 | 0 | 1 (0.5%) |
dhfr | N51I | 36 (92.3%) | 54 (77.1%) | 75 (86.2%) | 165 (84.2%) |
dhfr | C59R | 37 (94.9%) | 62 (88.6%) | 81 (93.1%) | 180 (91.8%) |
dhfr | S108N | 38 (97.4%) | 64 (91.4%) | 81 (93.1%) | 183 (93.4%) |
dhfr | S108T | 0 | 0 | 0 | 0 |
dhfr | I164L | 0 | 0 | 0 | 0 |
dhfr | I164M | 0 | 0 | 0 | 0 |
dhps | S436A | 19 (48.7%) | 42 (60.0%) | 54 (62.1%) | 115 (58.7%) |
dhps | S436F | 1 (2.6%) | 0 | 2 (2.3%) | 3 (1.5%) |
dhps | A437G | 36 (92.3%) | 61 (87.1%) | 80 (92%) | 177 (90.3%) |
dhps | K540E | 0 | 0 | 0 | 0 |
dhps | K540N | 0 | 0 | 0 | 0 |
dhps | A581G | 2 (5.1%) | 2 (2.9%) | 0 | 4 (2.0%) |
dhps | A613S | 6 (15.4%) | 8 (11.4%) | 13 (14.9%) | 27 (13.8%) |
dhps | A613T | 0 | 0 | 0 | 0 |
mdr1 | N86Y | 0 | 2 (2.9%) | 1 (1.2%) | 3 (1.5%) |
mdr1 | Y184F | 27 (69.2%) | 49 (70.0%) | 63 (72.4%) | 139 (70.9%) |
kelch13 | - | 0 | 0 | 0 | 0 |
